Jauwan Scaife added 17 points as he surpassed the 1,000-point milestone for his career, becoming the 26th Ball State player ever to do so.
Majok added a game-high 13 rebounds to his game-high 26 points for his second straight double-double and his sixth of the season.
The Cardinals dropped to 7-8 (1-2 Mid-American Conference) with the loss, while Akron ran its winning streak to eight games to improve to 12-4 (3-0 MAC).
Ball State returns to action Saturday with another road game at Central Michigan, which will be televised by the Ball State Sports Network. Tipoff is set for 7 p.m. as the Cardinals play their third road game in their first four league contests.
Wednesday at Akron, Ball State built at 28-22 lead in the closing minutes of the first half before a 12-0 Akron run going into the break changed the course of the game. The Zips extended their lead to as many as 10 points early in the second half, but the Cardinals never let the MAC leaders get out of reach.
Back-to-back 3-pointers from Scaife trimmed the Akron lead to one at 47-46 midway through the second half and put the Muncie native over the 1,000-point mark.
The Zips pushed the lead back to eight, but the Cardinals pulled within four at 61-57 on a lay-in by Majok with 3:20 to play and then got the ball back on an Akron turnover. Ball State had a chance to cut the lead even further but Marcus Posley's 3-pointer from the corner came up short.
Akron's Demetrius Treadwell converted a lay-in on the other end and then Alex Abreu knocked down a trey to push the Akron lead to 66-57 with 1:04 to play. From there, the Zips polished off the game at the free throw line.
Nick Harney led Akron with 15 points on the night, while Zeke Marshall scored 13 and Abreu added 11. Chris Bond joined Majok and Scaife in double figures for Ball State with 10 points and also added eight rebounds.
The Cardinals made a point out of feeding the post, scoring 32 points in the paint against a long Akron front line that includes Marshall, the MAC leader in blocked shots. Majok connected on 10 of his 16 attempts for the Cardinals against the Zips post players.
Ball State finished the game shooting 44.4 percent to Akron's 41.2 percent and held a 33-32 rebounding advantage over the Zips.